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SPECTRUM Newsletter

The Guthy-Jackson Charitable Foundation's Newsletter

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AAN 2010 Annual Meeting

A scientific conference to be held in Toronto, Canada, from April 10, 2010 to April 17, 2010.

European Neurological Society 20th Meeting

A scientific conference to be held in Berlin, Germany, from June 19, 2010 to June 23, 2010.

3rd Latin American Congress on Autoimmunity

A scientific conference to be held in Buenos Aires, Argentina, from July 1, 2010 to July 3, 2010.

PACTRIMS

A scientific conference to be held in Bali, Indonesia, from Aug 26, 2010 to Aug 28, 2010.

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Intra-cerebral injection of neuromyelitis optica immunoglobin G and human complement produces neuromyelitis optica lesions in mice (1607K)

Neuromyelitis optica is an inflammatory demyelinating disease of the central nervous system associated with autoantibodies against the glial water channel protein aquaporin-4. It has recently been reported that immunoglobulin from neuromyelitis optica patients injected peripherally does not cause lesions in naive rats, but only when pre-existing central nervo....

Spectrum Newsletter, Volume 1, Summer, 2009. (419K)

The summer edition of Spectrum, a newsletter from the Guthy-Jackson Foundation about the various aspects of Neuromyelitis Optica (NMO).

Features in this edition include details about the first patient repository, where people who have NMO can donate blood samples for scientific study. Dr. Ben Greenberg, from the University of Texas, Southwestern, answers some fr....

The antiinflammatory activity of IgG: the intravenous IgG paradox (1924K)

How high doses of intravenous IgG (IVIG) suppress autoimmune diseases remains unresolved. We have recently shown that the antiinflammatory activity of IVIG can be attributed to a minor species of IgGs that is modified with terminal sialic acids on their Fc-linked glycans. Here we propose that these Fc-sialylated IgGs engage a unique receptor on macrophages that, in turn, l....

Aquaporin-4: binding autoantibodies in patients with neuromyelitis optica impair glutamate transport by down-regulating EAAT2 (3966K)

Neuromyelitis optica (NMO)-immunoglobulin G (IgG) is a clinically validated serum biomarker that distinguishes relapsing central nervous system (CNS) infl ammatory demyelinating disorders related to NMO from multiple sclerosis. This autoantibody targets astrocytic aquaporin-4 (AQP4) water channels. Clinical, radiological, and immunopathological data suggest that NMO-IgG mi....
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Founders' Message

"As we collaborate on this journey, we have the opportunity to fund basic science research to find answers that will lead to prevention, clinical treatments, and an eventual cure for NMO Spectrum Disease."

Bill Guthy and Victoria Jackson, Founders
The Guthy-Jackson Charitable Foundation